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Updated: Aug 7, 2026

Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens
Published on: May 23, 2014
[Abnormal endometrial reactivity to colony stimulating factor 1 and leukemia inhibitory factor dependent female
G Laprée-Delage1, J F Moreau, J L Taupin
1Laboratoire de Biologie cellulaire et moléculaire de la relation materno-foetale, INSERM CJF 92-09/DRED JE 370, Bâtiment de Gynécologie-Obstétrique, Hôpital Antoine-Béclère, Clamart.
Abstract:
Maternal LIF is essential for embryo implantation in mice and it may also be the case in humans. We recently reported that endometrial LIF secretion from infertile women presenting repeated failures of embryonic implantation or unexplained sterility was significantly lower than the secretion of explants from fertile women. We now report on the modulation of the endometrial LIF secretion according to the obstetrical status. CSF-1 has little effect or increases LIF secretion from fertile women whereas it inhibits secretion from infertile women with repeated failures of embryonic implantation.
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