Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Histocompatibility (HL-A) antigens and primary open-angle glaucoma

Z Aviner, W L Henley, M Fotino

    Tissue Antigens
    |April 1, 1976
    PubMed
    Summary

    The human leukocyte antigen (HLA) Bw35 antigen was found more frequently in patients with open-angle glaucoma (OAG) and their relatives. This suggests a potential genetic link between Bw35 and OAG susceptibility.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Penetration of penicillin into the rabbit's eye with normal, inflamed, and abraded cornea.

    American journal of ophthalmology·2010
    Same author

    Symmetrical defects in the lower lids associated with abnormalities of the zygomatic processes of the temporal bone.

    American journal of ophthalmology·2010
    Same author

    The effects of di-isopropyl fluorophosphate upon normal and glaucomatous eyes.

    Federation proceedings·2010
    Same author

    Use of diisopropyl fluorophosphate (PFP) in treatment of glaucoma.

    Archives of ophthalmology (Chicago, Ill. : 1929)·2010
    Same author

    Effect of diisopropyl fluorophosphate (PFP) on the normal eye.

    Archives of ophthalmology (Chicago, Ill. : 1929)·2010
    Same author

    Symmetric defects in the lower lids associated with abnormalities of the zygomatic processes of the temporal bones.

    Archives of ophthalmology (Chicago, Ill. : 1929)·2010

    Area of Science:

    • Immunogenetics
    • Ophthalmology

    Background:

    • Open-angle glaucoma (OAG) is a leading cause of irreversible blindness.
    • The genetic factors contributing to OAG susceptibility are not fully understood.
    • Human leukocyte antigen (HLA) systems play a crucial role in immune responses and have been implicated in various diseases.

    Purpose of the Study:

    • To investigate the potential association between specific HLA antigens and open-angle glaucoma.
    • To determine if HLA antigen frequencies differ between OAG patients and the general population.

    Main Methods:

    • The study utilized the microcytotoxicity method to determine HLA antigen frequencies.
    • Frequencies of 25 HLA antigens were analyzed in 49 OAG patients and 22 patients with other causes of elevated intraocular pressure.

    Related Experiment Videos

  • Results were compared to 250 individuals from the general population and 27 first-degree relatives of OAG patients.

    • Main Results:

    • A statistically significant higher incidence of the Bw35 antigen was observed in OAG patients (p < 0.012).
    • An increased frequency of the Bw35 antigen was also noted in first-degree relatives of OAG patients compared to the general population.
    • These findings suggest a potential genetic predisposition linked to the Bw35 antigen.

    Conclusions:

    • The study indicates a significant association between the Bw35 antigen and open-angle glaucoma.
    • The Bw35 antigen or linked HLA loci may represent genetic factors influencing susceptibility to OAG.
    • Further research is needed to elucidate the biological significance of this association.