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[Etiologic factors for purulent meningitis in children. Twenty years of personal observations]
M Patrzałek1, B Natwora-Gołabek
1Oddział Zakaźny A Wojewódzkiego Specjalistycznego Szpitala Dzieciecego w Kielcach.
Abstract:
Etiological agents in purulent meningitis cases hospitalized during two 9 years periods: 1977-1985 and 1988-1996 were compared. While the percentage of cases caused by Neisseria meningitidis was similar in the two analyzed periods (55.7% i 66.5%, respectively), the percentage of cases caused by Streptococcus pneumoniae decreased from 33.5% to 8.4% and the percentages of cases caused by Haemophilus influenzae type b increased from 0.6% to 14.2%. The analysis of the sensitivity of isolated strains of H. influenzae type b shows the occurrence of strains resistant to ampicillin and chloramphenicol.
Insights
Purulent meningitis cases show a decrease in Streptococcus pneumoniae and an increase in Haemophilus influenzae type b. Antibiotic resistance in H. influenzae type b strains was also observed.
Area of Science:
- * Infectious Diseases
- * Microbiology
- * Epidemiology
Context:
- * Analysis of etiological agents in purulent meningitis cases hospitalized between 1977-1985 and 1988-1996.
- * Comparison of bacterial prevalence over two distinct 9-year periods.
Purpose:
- * To compare the etiological agents responsible for purulent meningitis over two decades.
- * To identify shifts in the prevalence of key bacterial pathogens.
- * To assess the antimicrobial sensitivity of identified pathogens, particularly Haemophilus influenzae type b.
Summary:
- * Neisseria meningitidis remained a consistent cause of meningitis (55.7% to 66.5%).
- * Streptococcus pneumoniae decreased significantly as a causative agent (33.5% to 8.4%).
- * Haemophilus influenzae type b (Hib) showed a marked increase (0.6% to 14.2%), with observed resistance to ampicillin and chloramphenicol.
Impact:
- * Highlights a significant epidemiological shift in the causative agents of bacterial meningitis.
- * Underscores the emerging challenge of antibiotic resistance in Haemophilus influenzae type b.
- * Informs public health strategies and treatment guidelines for managing bacterial meningitis.