[Nicotine metabolism in the pig (author's transl)]

After i.v. injection of 0.33 mg nicotine/kg the elimination of unchanged nicotine as well as nicotine-N-oxide, cotinine, nornicotine and norcotinine was determined in the urine of pigs dependent on time. In female pigs 16.3% and in male pigs 25.9% of the applied nicotine were recovered in form of the mentioned compounds within 31h. Nicotine elimination essentially stopped in the collecting period 3-8 h. The main decomposition products nicotine-N-oxide and cotinine were eliminated to a significant extent also 8-23 h after application.