Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Inhalation route for administration of systemic drugs]

J P Mallet1, P Diot, E Lemarié

  • 1Service de Pneumologie, CHU Bretonneau, Tours.

Revue Des Maladies Respiratoires
|December 31, 1997
PubMed
Summary

Aerosolized medicine delivery directly targets the lungs for topical or systemic effects. The intrapulmonary behavior of each drug must be individually studied for predictable outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lack of essential medical resources leaves Africa breathless.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2021
Same author

Evaluation of two shaping systems and two sonic irrigation devices in removing root canal filling material from distal roots of mandibular molars assessed by micro CT.

International endodontic journal·2019
Same author

Insights on animal models to investigate inhalation therapy: Relevance for biotherapeutics.

International journal of pharmaceutics·2017
Same author

[The pentoxifylline, a corticosteroid sparing in the treatment of sarcoidosis: A case report].

Revue de pneumologie clinique·2017
Same author

Impact on the medical decision-making process of multiplex PCR assay for respiratory pathogens.

Epidemiology and infection·2017
Same author

[Adaptive servo-ventilation after the SERVE-HF study: The swan song?].

Revue des maladies respiratoires·2016

Area of Science:

  • Pharmacology
  • Respiratory Medicine
  • Drug Delivery Systems

Context:

  • Aerosolized administration offers direct lung access for therapeutic agents.
  • The lung's extensive vascular network facilitates both local and systemic drug distribution.
  • The intrapulmonary behavior of inhaled molecules is molecule-specific and requires individual investigation.

Purpose:

  • To explore the dual potential of aerosolized drug administration for pulmonary topical or systemic effects.
  • To highlight the necessity of understanding individual molecule behavior within the lungs.
  • To categorize drugs based on their observed effects after aerosol administration.

Summary:

  • Inhaled medications can exert direct topical effects on the lungs or achieve systemic action via absorption through the lung's vasculature.
  • Drug behavior post-inhalation varies significantly; some intended for systemic use may act topically (e.g., furosemide, morphine), while others achieve systemic effects (e.g., insulin, nicotine).
  • Heparin's classification depends on dosage and administration specifics, demonstrating the nuanced outcomes of aerosolized therapy.

Impact:

  • Provides a framework for understanding and predicting the therapeutic outcomes of aerosolized medications.
  • Informs the development of targeted drug delivery strategies for respiratory and systemic diseases.
  • Highlights the importance of personalized approaches in aerosol therapy based on drug properties and intended use.

Related Experiment Videos