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New lipid lowering drugs and new effects of old drugs
1Arteriosclerosis and Metabolic Clinic, Kansas University Hospital, Kansas City 66160-7374, USA.
Current Opinion in Lipidology
|December 31, 1997
Abstract:
Old lipid acting drugs (fibrates, resins and niacin) continue to demonstrate morbidity and mortality benefits with variable efficacy and safety. Controlled trials have provided efficacy and safety data that support the use of statins as the first choice in the treatment and prevention of atherosclerosis. Knowledge of old and new mechanisms of action, optimal doses, pharmacokinetic behavior and drug interactions improve the safety and effectiveness of these hypolipidemic agents.