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Pain in multiple leiomyomas alleviated by nifedipine
S George1, S Pulimood, M Jacob
1Department of Dermatology, Christian Medical College & Hospital, Tamilnadu, India. abraham@cmc.ernet.in
Pain
|December 31, 1997
Summary
Nifedipine effectively treats pain from multiple skin leiomyomata. This calcium channel blocker significantly reduced discomfort in a patient with numerous histologically confirmed lesions.
Area of Science:
- Dermatology
- Pharmacology
- Medical Research
Background:
- Skin leiomyomata are benign tumors that can cause significant pain.
- Treatment options for symptomatic skin leiomyomata are limited.
- Pain associated with leiomyomata can be exacerbated by environmental factors like cold weather.
Observation:
- A 28-year-old female patient presented with hundreds of histologically confirmed skin leiomyomata.
- The patient experienced marked pain from these lesions, particularly during winter.
- The pain significantly impacted the patient's quality of life.
Findings:
- Nifedipine, a calcium channel blocker, was administered at 10 mg, three to four times daily.
- The patient showed a remarkable reduction in pain associated with the skin leiomyomata.
- The therapeutic effect of nifedipine was clearly demonstrated in managing leiomyoma-associated pain.
Implications:
- Nifedipine represents a potentially effective therapeutic option for managing pain in multiple cutaneous leiomyomata.
- Further clinical studies are warranted to confirm the efficacy and safety of nifedipine for this condition.
- This finding may offer a new treatment avenue for patients suffering from painful skin leiomyomata.