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[Chronic renal failure and guanidino compounds]
1School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|January 1, 1998
Summary
Uremic toxins like guanidino succinic acid and methyl guanidine increase in kidney failure. Methyl guanidine levels may indicate active oxygen generation, suggesting antioxidants could treat uremia.
Area of Science:
- Nephrology
- Toxicology
- Biochemistry
Context:
- Uremic toxins accumulate in renal failure, impacting patient health.
- Guanidino succinic acid (GSA) and methyl guanidine (MG) are key toxins studied in nephritis.
- GSA correlates with blood urea nitrogen, indicating reduced kidney function.
Purpose:
- To investigate the role of GSA and MG as markers of renal failure.
- To explore the relationship between MG, creatinine (CTN), and active oxygen generation.
- To assess the potential therapeutic value of active oxygen scavengers in uremia.
Summary:
- Guanidino compounds, including GSA and MG, are elevated in renal failure.
- GSA serves as a marker for decreased renal function.
- MG levels rise sharply in severe uremia and are linked to active oxygen production via CTN oxidation, with the MG/CTN ratio reflecting oxidative stress.
Impact:
- Highlights GSA and MG as important biomarkers for assessing kidney disease progression.
- Suggests the MG/CTN ratio as a novel indicator of oxidative stress in uremia.
- Proposes active oxygen scavengers as a potential therapeutic strategy for managing uremia.