Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthetic Biology02:55

Synthetic Biology

5.5K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
5.5K
Combinatorial Gene Control02:33

Combinatorial Gene Control

9.5K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
9.5K
Next-generation Sequencing03:00

Next-generation Sequencing

97.9K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
97.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long-term in vivo degradation of Mg-Zn-Ca elastic stable intramedullary nails and their influence on the physis of juvenile sheep.

Biomaterials advances·2023
Same author

["Legal highs" (new psychoactive substances) : What does the anesthesiologist need to know?]

Der Anaesthesist·2020
Same author

[Efficacy of biofeedback in patients with chronic low back pain : Impact on pain intensity, psychological factors and stress markers].

Schmerz (Berlin, Germany)·2019
Same author

Comparison of a resorbable magnesium implant in small and large growing-animal models.

Acta biomaterialia·2018
Same author

Chronic intrahypothalamic rather than subcutaneous liraglutide treatment reduces body weight gain and stimulates the melanocortin receptor system.

International journal of obesity (2005)·2017
Same author

Long-term in vivo degradation behavior and near-implant distribution of resorbed elements for magnesium alloys WZ21 and ZX50.

Acta biomaterialia·2016

Related Experiment Video

Updated: Jan 18, 2026

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

3.0K

Generation and utilization of synthetic combinatorial libraries

J Eichler1, R A Houghten

  • 1Torrey Pines Institute for Molecular Studies, San Diego, CA 92121, USA.

Molecular Medicine Today
|July 1, 1995
PubMed
Summary

Combinatorial chemistry rapidly advances research and drug discovery by creating vast molecular diversity using synthetic libraries. These libraries yield highly active compounds like receptor ligands and enzyme inhibitors.

More Related Videos

Rapid Characterization of Genetic Parts with Cell-Free Systems
05:00

Rapid Characterization of Genetic Parts with Cell-Free Systems

Published on: August 30, 2021

2.2K
Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
10:58

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries

Published on: September 6, 2012

10.7K

Related Experiment Videos

Last Updated: Jan 18, 2026

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids
08:21

Curation of Computational Chemical Libraries Demonstrated with Alpha-Amino Acids

Published on: April 13, 2022

3.0K
Rapid Characterization of Genetic Parts with Cell-Free Systems
05:00

Rapid Characterization of Genetic Parts with Cell-Free Systems

Published on: August 30, 2021

2.2K
Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
10:58

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries

Published on: September 6, 2012

10.7K

Area of Science:

  • Medicinal Chemistry
  • Organic Chemistry
  • Biotechnology

Background:

  • Combinatorial chemistry is revolutionizing scientific research and drug discovery.
  • Synthetic peptide libraries have enabled the generation of immense molecular diversity.

Purpose of the Study:

  • To review methods for generating and applying combinatorial libraries, focusing on soluble synthetic libraries.
  • To highlight the utility of molecular diversity in basic research and drug discovery.

Main Methods:

  • Review of established and emerging techniques for combinatorial library synthesis.
  • Emphasis on the preparation and application of soluble synthetic combinatorial libraries.
  • Analysis of diverse compound identification from these libraries.

Main Results:

  • Combinatorial chemistry enables the creation of vast molecular diversities.
  • Soluble synthetic combinatorial libraries are particularly effective.
  • Numerous highly active compounds have been identified, including antigenic peptides, receptor ligands, antimicrobial compounds, and enzyme inhibitors.

Conclusions:

  • Combinatorial chemistry significantly accelerates the pace and broadens the scope of research and drug discovery.
  • The identified compounds demonstrate the practical utility of combinatorial libraries in identifying novel therapeutic agents.
  • Further development and application of these libraries hold great promise for future scientific advancements.