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Chemotherapy-induced myocardial necrosis in a patient with chronic lymphocytic leukemia
1Yale University School of Medicine, General Internal Medicine Section 111, West Haven V.A. Medical Center, CT 06516, USA.
Respiratory Medicine
|January 31, 1998
Abstract:
Cardiac toxicity following the administration of chemotherapeutic agents is well documented. Vinca alkaloids, as well as high-dose cyclophosphamide, have been associated with myocardial ischemia. The present report describes a case of acute myocardial infarction occurring in a patient with no antecedent cardiac history who received both vincristine and conventional chemotherapeutic doses of cyclophosphamide for the treatment of chronic lymphocytic leukemia. Physicians should possess a heightened awareness of this potentially serious complication.