Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rod inputs to macaque ganglion cells

B B Lee1, V C Smith, J Pokorny

  • 1Max Planck Institute for Biophysical Chemistry, Göttingen, Germany. blee@gwdg.del

Vision Research
|February 12, 1998
PubMed
Summary

Rod inputs significantly impact retinal ganglion cells, particularly in the magnocellular pathway, even at low light levels. Parvocellular cells show weaker rod influence, with responses mainly driven by cones.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A modified silent substitution electroretinography protocol to separate photoreceptor subclass function in lightly sedated dogs.

Veterinary ophthalmology·2020
Same author

Impact of network topology on the stability of DC microgrids.

Chaos (Woodbury, N.Y.)·2019
Same author

Abdominal Functional Electrical Stimulation to Augment Respiratory Function in Spinal Cord Injury.

Topics in spinal cord injury rehabilitation·2019
Same author

Human S-cone electroretinograms obtained by silent substitution stimulation.

Journal of the Optical Society of America. A, Optics, image science, and vision·2018
Same author

Characteristics of CSF Velocity-Time Profile in Posttraumatic Syringomyelia.

AJNR. American journal of neuroradiology·2017
Same author

The morphology of human rod ERGs obtained by silent substitution stimulation.

Documenta ophthalmologica. Advances in ophthalmology·2017

Area of Science:

  • Neuroscience
  • Vision Science
  • Retinal Physiology

Background:

  • Understanding rod and cone photoreceptor contributions to retinal ganglion cell function is crucial for visual processing.
  • The relative roles of rod and cone pathways in dim light vision remain an active area of research.

Purpose of the Study:

  • To quantify the strength and characteristics of rod inputs to ganglion cells in the macaque retina.
  • To compare rod pathway sensitivity and latency between the parvocellular (PC) and magnocellular (MC) visual pathways.

Main Methods:

  • Utilized temporally modulated heterochromatic lights with varying relative phase to sensitively detect rod input.
  • Assessed responses in PC and MC pathway cells at retinal eccentricities of 3-15 degrees.
  • Measured cell responses across a range of retinal illuminances (e.g., 2 td, 20 td).

Main Results:

  • Weak rod responses (few impulses/sec) were detected in ~60% of PC cells at 2 td, while blue-on cells showed no rod response.
  • MC pathway cells exhibited more apparent rod input, becoming rod-dominated at or below 20 td.
  • Rod responsivity was maintained at low retinal illuminances in MC cells, with observed temporal-frequency dependent rod-cone interactions.

Conclusions:

  • Rod input plays a more substantial role in the magnocellular pathway than the parvocellular pathway, especially in dim light.
  • While rod responses have longer latencies than cone responses, this latency difference is consistent across both PC and MC pathways.
  • The findings highlight differential rod-cone integration across retinal pathways, impacting visual perception in varying light conditions.

Related Experiment Videos