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Laryngotracheoesophageal clefts
1Division of Pediatric Otolaryngology, Children's Memorial Hospital, and Northwestern University Medical School, Chicago, Illinois 60614, USA.
The Annals of Otology, Rhinology, and Laryngology
|January 10, 1998
Summary
Laryngeal cleft anomalies, including submucous and laryngotracheoesophageal types, were identified in 11 of 115 specimens. This review details their pathology, classification, and clinical management.
Area of Science:
- Pediatric Pathology
- Developmental Biology
- Otolaryngology
Background:
- Laryngeal cleft anomalies are rare congenital malformations.
- Understanding their classification and pathology is crucial for diagnosis and management.
Purpose of the Study:
- To review laryngeal cleft anomalies based on a series of laryngeal specimens.
- To discuss the classification, histopathology, and clinical aspects of these anomalies.
Main Methods:
- Review of 115 laryngeal specimens collected between 1975 and 1995.
- Detailed histopathologic examination of identified anomalies.
- Literature review on laryngeal clefts.
Main Results:
- 11 of 115 specimens (9.6%) exhibited laryngeal cleft anomalies.
- Eight cases of submucous laryngeal cleft were found.
- Three cases of laryngotracheoesophageal clefts were identified (one Type II, two Type III).
Conclusions:
- Laryngeal cleft anomalies encompass a spectrum of abnormalities with distinct histopathologic features.
- Accurate classification and understanding of embryology aid in clinical evaluation and management.
- Further research into the embryogenesis and clinical outcomes is warranted.