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Ascorbic acid absorption in patients with systemic sclerosis

L S Teh1, C W Johns, J L Shaffer

  • 1Rheumatic Diseases Centre, Radioisotope Department, University of Manchester, UK.

The Journal of Rheumatology
|February 7, 1998
PubMed
Summary
This summary is machine-generated.

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Systemic sclerosis patients without bacterial overgrowth do not show impaired ascorbic acid absorption. This study found similar vitamin C uptake and clearance in patients and healthy controls, ruling out malabsorption as a cause.

Area of Science:

  • Biochemistry
  • Clinical Nutrition
  • Rheumatology

Background:

  • Systemic sclerosis (SSc) is associated with reduced circulating ascorbic acid levels.
  • The cause of this deficiency, specifically potential malabsorption, remains unclear in SSc patients without bacterial overgrowth.

Purpose of the Study:

  • To investigate whether malabsorption contributes to reduced ascorbic acid levels in systemic sclerosis patients.
  • To compare ascorbic acid absorption in SSc patients and healthy controls.

Main Methods:

  • Oral administration of radiolabeled [14C] ascorbic acid followed by unlabeled ascorbic acid flush-out.
  • Measurement of plasma and urine [14C] levels over 8 days to assess absorption.
  • Calculation of area under the curve (AUC) and apparent renal clearance (CLr[app]) for ascorbic acid.

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Main Results:

  • No significant differences in dietary vitamin C intake or body mass index between SSc patients and controls.
  • Identical plasma [14C] AUC and CLr(app) values were observed in both SSc patients and healthy controls.
  • These findings indicate comparable ascorbic acid absorption and clearance between the groups.

Conclusions:

  • Impaired absorption of ascorbic acid is not a contributing factor to vitamin C deficiency in SSc patients without bacterial overgrowth.
  • The results suggest that other mechanisms may be responsible for reduced ascorbic acid levels in this patient population.