The role of innovation in drug development

Sensing glucose concentrations at GHz frequencies with a fully embedded Biomicro-electromechanical system (BioMEMS).

Journal of applied physics·2014

Induction of p38, tumour necrosis factor-α and RANTES by mechanical stretching of keratinocytes expressing mutant keratin 10R156H.

The British journal of dermatology·2010

Levels of parotid and submandibular/sublingual salivary immunoglobulin A in response to experimental gingivitis in humans.

Clinical oral investigations·2004

[Mycotic aneurysms--A retrospective analysis].

Zentralblatt fur Chirurgie·2002

MAP kinase phosphatase-1 gene transcription in rat neuroendocrine cells is modulated by a calcium-sensitive block to elongation in the first exon.

The Journal of biological chemistry·2001

Heme histidine ligands within gp91(phox) modulate proton conduction by the phagocyte NADPH oxidase.

The Journal of biological chemistry·2001

AI-enhanced adaptive virtual screening of large libraries for ligand discovery.

Nature biotechnology·2026

A pervasive RT-qPCR artifact inflates RNA knockdown by RNA-targeting CRISPR.

Nature biotechnology·2026

Macropinocytosis-mediated recyclable LYTACs (McR-TACs) for receptor-independent protein degradation.

Nature biotechnology·2026

A genomic catalog of Earth's bacterial and archaeal symbionts.

Nature biotechnology·2026

Precise genomic integration of large DNA fragments by donor-directed annealing using prime editing.

Nature biotechnology·2026

Donor-complementary prime editing enables precise kilobase and library-compatible DNA insertions.

Nature biotechnology·2026

Rational drug design, synthetic and artificial intelligence approaches for bioactive heterocycles: advances and perspectives.

Future medicinal chemistry·2026

Design and synthesis of 1,3,4-oxadiazole-tethered N-substituted isatin hybrids as SARS-CoV-2 main protease inhibitors: biological evaluation, kinetic investigation, and in silico studies.

RSC advances·2026

Teaching diffusion models physics: reinforcement learning for physically valid diffusion-based docking.

Chemical science·2026

Similarity-Enhanced Representation Learning of Non-Canonical Amino Acids for Therapeutic Peptide Modeling.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026

Machine Learning Approaches for Interpretable Antibody Property Prediction Using Structural Data.

Methods in molecular biology (Clifton, N.J.)·2026

New thinking for the next generation of antimalarials.

EMBO molecular medicine·2026

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The role of innovation in drug development

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Sensing glucose concentrations at GHz frequencies with a fully embedded Biomicro-electromechanical system (BioMEMS).

Induction of p38, tumour necrosis factor-α and RANTES by mechanical stretching of keratinocytes expressing mutant keratin 10R156H.

Levels of parotid and submandibular/sublingual salivary immunoglobulin A in response to experimental gingivitis in humans.

[Mycotic aneurysms--A retrospective analysis].

MAP kinase phosphatase-1 gene transcription in rat neuroendocrine cells is modulated by a calcium-sensitive block to elongation in the first exon.

Heme histidine ligands within gp91(phox) modulate proton conduction by the phagocyte NADPH oxidase.

AI-enhanced adaptive virtual screening of large libraries for ligand discovery.

A pervasive RT-qPCR artifact inflates RNA knockdown by RNA-targeting CRISPR.

Macropinocytosis-mediated recyclable LYTACs (McR-TACs) for receptor-independent protein degradation.

A genomic catalog of Earth's bacterial and archaeal symbionts.

Precise genomic integration of large DNA fragments by donor-directed annealing using prime editing.

Donor-complementary prime editing enables precise kilobase and library-compatible DNA insertions.

Rational drug design, synthetic and artificial intelligence approaches for bioactive heterocycles: advances and perspectives.

Design and synthesis of 1,3,4-oxadiazole-tethered N-substituted isatin hybrids as SARS-CoV-2 main protease inhibitors: biological evaluation, kinetic investigation, and in silico studies.

Teaching diffusion models physics: reinforcement learning for physically valid diffusion-based docking.

Similarity-Enhanced Representation Learning of Non-Canonical Amino Acids for Therapeutic Peptide Modeling.

Machine Learning Approaches for Interpretable Antibody Property Prediction Using Structural Data.

New thinking for the next generation of antimalarials.

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The role of innovation in drug development

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