Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Emotional memory and psychopathology

J E Ledoux1, J Muller

  • 1Department of Psychology, New York University, NY 10003, USA. ledoux@cns.nyu.edu

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
|January 7, 1998
PubMed
Summary

Fear conditioning research reveals the brain circuits for emotional memory. Understanding these neural pathways and cellular mechanisms in the amygdala may improve treatments for emotional disorders.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Activation of a novel p70 S6 kinase 1-dependent intracellular cascade in the basolateral nucleus of the amygdala is required for the acquisition of extinction memory.

Molecular psychiatry·2017
Same author

The birth, death and resurrection of avoidance: a reconceptualization of a troubled paradigm.

Molecular psychiatry·2016
Same author

Indelibility of subcortical emotional memories.

Journal of cognitive neuroscience·2013
Same author

Computational modeling of emotion: explorations through the anatomy and physiology of fear conditioning.

Trends in cognitive sciences·2011
Same author

Is it time to invoke multiple fear learning systems in the amygdala?

Trends in cognitive sciences·2011
Same author

Ultrastructural characterization of noradrenergic axons and Beta-adrenergic receptors in the lateral nucleus of the amygdala.

Frontiers in behavioral neuroscience·2010

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Behavioral Science

Background:

  • Fear conditioning is a key model for studying how the brain forms memories of unpleasant experiences.
  • Previous research has identified major neural systems involved in this learning process.

Purpose of the Study:

  • To elucidate the neural pathways and cellular mechanisms underlying fear conditioning.
  • To advance the understanding of emotional memory at the cellular and synaptic levels.

Main Methods:

  • Investigating sensory information transmission from the thalamus and cortex to the amygdala.
  • Analyzing the roles of the amygdala's lateral and central nuclei in integrating sensory input and mediating fear responses.
  • Identifying sites of plasticity and cellular mechanisms within the fear conditioning circuitry.

Main Results:

  • Sensory information travels from the thalamus and cortex to the amygdala.
  • The lateral nucleus of the amygdala integrates sensory inputs, while the central nucleus interfaces with motor systems for fear responses.
  • Internal amygdala connections facilitate communication between nuclei, and plasticity sites are being identified.

Conclusions:

  • Fear conditioning studies are deepening our understanding of emotional memory at the cellular and synaptic levels.
  • Advances in this field offer potential for better definition and treatment of emotional disorders.

Related Experiment Videos