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The T cell surface protein, CD28

C E Edmead1, J R Lamb, G F Hoyne

  • 1Department of Biology, Imperial College of Science, Technology and Medicine, London, U.K.

The International Journal of Biochemistry & Cell Biology
|August 1, 1997
PubMed
Summary
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The CD28 receptor on T cells, when engaged by B7 on antigen-presenting cells, enhances T cell activation. Manipulating this CD28/B7 interaction offers therapeutic potential for immune disorders and cancer.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • CD28 is a constitutively expressed surface glycoprotein on T cells.
  • CD28 ligation by B7 on antigen-presenting cells provides co-stimulatory signals.
  • These signals synergize with T cell receptor engagement to enhance T cell responses.

Purpose of the Study:

  • To investigate the role of CD28/B7 interactions in T cell activation.
  • To explore the therapeutic potential of manipulating CD28 signaling pathways.

Main Methods:

  • The study focuses on the molecular interactions between CD28 and B7.
  • Analysis of T cell proliferation and cytokine production upon CD28/B7 engagement.
  • Exploration of blocking or enhancing CD28/B7 interactions.

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Main Results:

  • CD28/B7 co-stimulation significantly enhances T cell proliferation and cytokine production.
  • Blocking CD28/B7 interactions can prevent T cell activation.
  • Enhancing CD28/B7 interactions can promote anti-tumor responses.

Conclusions:

  • CD28/B7 interaction is a critical regulator of T cell activation.
  • Targeting CD28 signaling pathways holds promise for treating autoimmune diseases, allergies, and cancer.
  • CD28 represents a potential therapeutic target for immune modulation.