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Immunosuppression in dogs with pyoderma and/or demodicosis
M Toman1, M Svoboda, J Rybnícek
1Veterinary Research Institute, Brno, Czech Republic. kahr@vuvel.anet.cz
Veterinarni Medicina
|January 7, 1998
Summary
Deep pyoderma significantly suppresses the immune system in dogs, particularly German Shepherds. Demodicosis alone rarely causes immunosuppression, often requiring concurrent pyoderma.
Area of Science:
- Veterinary Immunology
- Canine Dermatology
Background:
- Pyoderma and demodicosis are common canine skin diseases.
- Immune system dysfunction can complicate these conditions.
Purpose of the Study:
- To investigate immune system activity in dogs with pyoderma and demodicosis.
- To identify correlations between specific conditions and immunosuppression.
Main Methods:
- Evaluated 66 dogs with pyoderma and/or demodicosis.
- Conducted leukocyte counts, differential counts, phagocytosis assays, lymphocyte transformation tests, and measured immunoglobulin, lysozyme, and complement levels.
Main Results:
- Immunosuppression occurred in 28.8% of cases, primarily associated with deep pyoderma.
- German Shepherds with deep pyoderma showed pronounced immunosuppression.
- Demodicosis alone did not cause immunosuppression; it was observed only with concurrent pyoderma.
Conclusions:
- Deep pyoderma is a significant factor in canine immunosuppression.
- Breed (German Shepherds) and disease severity influence the degree of immunosuppression.