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Ofloxacin-induced seizure
G D Walton1, J K Hon, T G Mulpur
1Department of Pharmacy, Huntsville Hospital, AL, USA.
The Annals of Pharmacotherapy
|January 7, 1998
Summary
Ofloxacin, a fluoroquinolone antibiotic, may trigger generalized tonic-clonic seizures, especially in patients with sepsis or impaired renal function. Caution is advised when prescribing fluoroquinolones to at-risk individuals.
Area of Science:
- Neurology
- Pharmacology
- Infectious Diseases
Background:
- Generalized tonic-clonic seizures are uncommon adverse effects of fluoroquinolone antibiotics.
- Patients with compromised renal function or sepsis may have an increased risk of seizures when treated with fluoroquinolones.
- Distinguishing drug-induced seizures from other causes, such as central nervous system metastases, is crucial for appropriate patient management.