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The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Risk factors for early work disability in systemic lupus erythematosus: results from a multicenter study
A J Partridge1, E W Karlson, L H Daltroy
1Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Arthritis and Rheumatism
|January 7, 1998
Summary
Systemic lupus erythematosus (SLE) can lead to early work disability. Lower education, physically demanding jobs, and higher disease activity are key risk factors for SLE patients quitting work.
Area of Science:
- Rheumatology
- Occupational Health
- Sociomedical Science
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple organ systems.
- Work disability is a significant concern for SLE patients, impacting their quality of life and economic stability.
Purpose of the Study:
- To identify risk factors associated with early work disability in patients with systemic lupus erythematosus (SLE).
Main Methods:
- A multicenter study included 159 employed SLE patients.
- Data collected via standardized interviews included disease activity, organ damage, sociodemographic factors, and work-related variables.
- Work disability was defined as self-reported cessation of work due to SLE.
Main Results:
- Approximately 40% of SLE patients experienced work disability within 3.4 years of diagnosis.
- Significant predictors of early work disability included lower education levels, jobs requiring more physical strength, and higher disease activity at diagnosis.
- Multivariate analysis confirmed education, job physical demands, and initial disease activity as significant factors.
Conclusions:
- Early work disability in SLE is significantly linked to sociodemographic factors and job characteristics.
- These identified factors may present opportunities for targeted interventions to support continued employment for SLE patients.
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