[Radiation-protective effect of agonists of alpha-2 adrenergic receptors. Methyldopa]

MethylDOPA has the considerable (60-80%) and lasting RPE at both intraperitoneal (0.5-3.8 mmol/kg) and per os (3.8-7.1 mmol/kg) introduction in radiation dose 8 Gr (LD97/30). Optimal time for introduction is 0.5-3.0 hours intraperitoneally and 3-6 hours per os. Evidently, methylDOPA RPE is realized via alpha 2-adrenoceptors.