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[Antibiotic-induced hemorrhagic cystitis]

F T Nielsen1, M K Hornstrup

  • 1Odense Universitetshospital, medicinsk afdeling C. ftn@dou.dk

Ugeskrift for Laeger
|January 7, 1998
PubMed
Summary

Two male patients experienced hemorrhagic cystitis after receiving methicillin and penicillin G. Symptoms resolved upon antibiotic discontinuation, suggesting a possible allergic reaction to penicillins.

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Area of Science:

  • Pharmacology
  • Urology

Background:

  • Antibiotic-induced adverse drug reactions can manifest in various clinical settings.
  • Hemorrhagic cystitis is a recognized, albeit rare, complication associated with certain medications.

Observation:

  • Two male patients, aged 24 and 45, presented with acute onset of hematuria, dysuria, and pollakisuria.
  • Both patients had recently been treated with methicillin and penicillin G, respectively.

Findings:

  • The presented cases link methicillin and penicillin G to hemorrhagic cystitis.
  • Symptoms resolved rapidly after cessation of antibiotic therapy.
  • The rapid resolution and history of cross-reactivity suggest an allergic mechanism.

Implications:

  • Clinicians should consider antibiotic-induced hemorrhagic cystitis in patients presenting with these urinary symptoms.
  • Awareness of potential cross-reactivity among penicillins is crucial for patient management.
  • Further investigation into the immunologic mechanisms of antibiotic-induced cystitis is warranted.

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