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The genetic reconstruction of BCG as a new immunotherapeutic tool
1Harvard Medical School, Beth Israel Deaconess Medical Center, Division of Urology, Boston, MA 02215, USA. modonnel@bidmc.harvard.edu
Trends in Biotechnology
|January 7, 1998
Abstract:
The bacillus of Calmette and Guérin (BCG), long appreciated for its role as a live vaccine for the prevention of tuberculosis, is undergoing a rebirth as a recombinant delivery vehicle for foreign antigens and bioactive proteins. Recombinant BCG causes long-lived specific humoral and cellular immunity and may ultimately prove to be a powerful and cost-effective new weapon against both infectious pathogens and certain cancers.