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Related Experiment Videos

Mifepristone (RU486): a review

D K Mahajan1, S N London

  • 1Department of Obstetrics and Gynecology, Louisiana State University School of Medicine, Shreveport 71130, USA. DMAHAJ@LSUMC.EDU

Fertility and Sterility
|January 7, 1998
PubMed
Summary

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Mifepristone (RU486) blocks progesterone receptors, terminating pregnancy and treating conditions like endometriosis and cancer. Future uses may include estrogen-free contraception.

Area of Science:

  • Pharmacology
  • Endocrinology
  • Gynecology

Background:

  • Mifepristone (RU486) is a synthetic steroid derivative.
  • It exhibits high affinity for progesterone and glucocorticoid receptors.

Purpose of the Study:

  • Review the mechanism of action and pharmacodynamics of mifepristone (RU486).
  • Explore potential new uses of mifepristone beyond its abortifacient role.
  • Examine its therapeutic applications in endometriosis, leiomyoma, breast cancer, and meningioma.

Main Methods:

  • Literature review of studies related to RU486.
  • MEDLINE database search for relevant publications.

Main Results:

  • Mifepristone competitively binds to progesterone receptors, inhibiting transcription of progesterone-dependent genes.
Keywords:
Abortion, Drug InducedAbortion, InducedBiologyBreast CancerCancerContraceptionContraceptive AgentsContraceptive Agents, FemaleContraceptive Agents, PostcoitalDiseasesEndocrine SystemEndometriumFamily PlanningFertility Control, PostconceptionFibroidsGenitaliaGenitalia, FemaleHormone AntagonistsHormonesLiterature ReviewNeoplasmsNeoplasms, BenignPhysiologyRu-486TreatmentUrogenital SystemUterus

Related Experiment Videos

  • It effectively blocks placental progesterone receptors, leading to pregnancy termination.
  • Clinical applications include treatment for leiomyomata, endometriosis, advanced breast cancer, and meningioma.

    • Conclusions:

    • Mifepristone is a potent progesterone receptor antagonist.
    • Its efficacy extends to various gynecological and oncological conditions.
    • Mifepristone serves as a valuable research tool and holds potential for future estrogen-free contraceptive development.