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Related Experiment Videos

Twenty proteins containing a C-terminal SOCS box form five structural classes

D J Hilton1, R T Richardson, W S Alexander

  • 1The Walter and Eliza Hall Institute for Medical Research and The Cooperative Research Center for Cellular Growth Factors, Parkville, Victoria 3050, Australia. hilton@wehi.edu.au

Proceedings of the National Academy of Sciences of the United States of America
|February 21, 1998
PubMed
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The suppressor of cytokines signaling (SOCS) box motif is found in 16 new proteins, expanding the SOCS family and revealing novel protein classes involved in cytokine regulation.

Area of Science:

  • Molecular Biology
  • Immunology
  • Genetics

Background:

  • The Suppressor of Cytokines Signaling (SOCS) family, including SOCS-1 to SOCS-3 and Cytokine-Inducible SH2-containing protein (CIS), negatively regulates cytokine signal transduction.
  • SOCS proteins share a conserved structure with an N-terminal region, a central SH2 domain, and a C-terminal SOCS box.

Purpose of the Study:

  • To identify novel proteins containing the SOCS box motif.
  • To classify these newly identified proteins based on their N-terminal domains.
  • To investigate the expression patterns and cytokine regulation of these protein families.

Main Methods:

  • Bioinformatic analysis of DNA databases using the SOCS box amino acid sequence consensus.
  • Protein motif analysis to classify identified proteins.

Related Experiment Videos

  • Expression analysis of representative protein members and their regulation by cytokines.

    • Main Results:

    • Identified 16 additional proteins containing the SOCS box motif.
    • Discovered four new SOCS proteins (SOCS-4 to SOCS-7) and three new protein families: WD-40 repeat-containing proteins (WSB-1, -2), SPRY domain-containing proteins (SSB-1 to -3), and ankyrin repeat-containing proteins (ASB-1 to -3).
    • Found that a class of small GTPases also contains a SOCS box, and expression patterns vary significantly among these protein families and their regulation by cytokines.

    Conclusions:

    • The SOCS box motif is present in a broader range of proteins than previously known, significantly expanding the SOCS superfamily.
    • The newly identified protein families (WSB, SSB, ASB) represent novel players in cellular signaling pathways, although their specific functions require further investigation.
    • Differential expression and cytokine regulation suggest specialized roles for these SOCS box-containing proteins in immune responses.