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Related Experiment Videos

Bronchial arterial response to contrast medium

E M Baile1, J R Mayo, F Sasaki

  • 1University of British Columbia Pulmonary Research Laboratory, St. Paul's Hospital, Vancouver, British Columbia, Canada.

Academic Radiology
|November 1, 1995
PubMed
Summary
This summary is machine-generated.

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Contrast agents like MD-76 increase bronchial blood flow, potentially worsening bleeding during procedures. This vasodilation is partly mediated by nitric oxide (NO).

Area of Science:

  • Vascular physiology
  • Radiology
  • Pharmacology

Background:

  • Contrast agents can cause vasodilation in various blood vessels.
  • The effect of contrast agents on bronchial vasculature is unknown.
  • Contrast-induced bronchial vasodilation may increase risks during procedures for hemoptysis.

Purpose of the Study:

  • To measure the bronchial vasodilatory response to diatrizoate meglumine 66% and diatrizoate sodium 10% (MD-76).
  • To investigate if nitric oxide (NO) mediates this vasodilatory response.

Main Methods:

  • Bronchial blood flow was measured in sheep using an ultrasonic flow probe.
  • MD-76 was injected into the bronchial artery before and after NO-synthase inhibition with N omega-nitro-L-arginine (L-NA).

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Main Results:

  • MD-76 injection caused a significant increase in bronchial blood flow (45 +/- 8 ml/min).
  • Pre-treatment with L-NA reduced the MD-76-induced increase in bronchial blood flow (to 20 +/- 6 ml/min).

Conclusions:

  • Bronchial arterial injection of MD-76 leads to increased bronchial blood flow.
  • This increase in blood flow is partially mediated by nitric oxide.