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Polyurethane-coated, self-expandable biliary stent: an experimental study

A Severini1, S Mantero, M C Tanzi

  • 1Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.

Academic Radiology
|December 1, 1995
PubMed
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A new polymeric coating for self-expanding metallic biliary stents was developed to prevent tissue growth. Functional tests confirmed the coating’s stability and did not compromise the stent’s performance, paving the way for in vivo studies.

Area of Science:

  • Biomaterials Science
  • Medical Device Engineering
  • Gastroenterology

Background:

  • Biliary duct obstruction is often treated with self-expanding metallic stents.
  • Neoplastic and reactive tissue growth within stents can lead to restenosis.
  • Polymeric coatings are being explored to improve stent performance and longevity.

Purpose of the Study:

  • To describe the development of a novel polymeric coating for Gianturco-Rösch biliary stents.
  • To evaluate the coating's ability to prevent tissue ingrowth.
  • To assess the mechanical properties and functional performance of the coated stents.

Main Methods:

  • Polyurethane (polycarbonate urethane) pellets were dissolved in dimethylacetamide.
  • Stents were coated using a solvent-casting technique, followed by solvent evaporation.

Related Experiment Videos

  • In vitro mechanical characterization included coating adhesion, introducer compatibility, and radial stress analysis.

    • Main Results:

    • The solvent-casting technique produced a smooth internal stent surface and a textured external surface.
    • Functional tests confirmed that the coating maintained stent self-expandability, axial flexibility, and radial rigidity.
    • Coating stability and device handling were verified, indicating suitability for further testing.

    Conclusions:

    • The developed polymeric coating shows promise for preventing tissue ingrowth in biliary stents.
    • The coated stents exhibit preserved mechanical properties and handling characteristics.
    • These findings support the progression to in vivo experimentation for clinical evaluation.