Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

X-linked ectodermal dysplasia in the dog

M L Casal1, P F Jezyk, J M Greek

  • 1Center for Comparative Medical Genetics, University of Pennsylvania, School of Veterinary Medicine, Philadelphia 19104-6010, USA.

The Journal of Heredity
|January 7, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Muscle growth in young horses: Effects of age, cytokines, and growth factors.

Journal of animal science·2015
Same author

HORSE SPECIES SYMPOSIUM: The aging horse: Effects of inflammation on muscle satellite cells.

Journal of animal science·2014
Same author

Autosomal Recessive Congenital Ichthyosis in American Bulldogs Is Associated With NIPAL4 (ICHTHYIN) Deficiency.

Veterinary pathology·2014
Same author

The dog as a natural animal model for study of the mammary myoepithelial basal cell lineage and its role in mammary carcinogenesis.

Journal of comparative pathology·2014
Same author

Prognostic evaluation of feline mammary carcinomas: a review of the literature.

Veterinary pathology·2014
Same author

CONGENITAL HEART DISEASE.

A listing of research in the cardiovascular field·2014
Same journal

Chromosome-scale genome assembly of the rice stink bug (Hemiptera: Oebalus pugnax) illuminates genome structure and gene family evolution in Pentatomidae.

The Journal of heredity·2026
Same journal

Rapid Derivation of Cloning-Competent Cells from Peripheral Blood Advances Conservation Biobanking.

The Journal of heredity·2026
Same journal

Genomic vulnerability to climate change of a poorly dispersing and threatened fish, the southern pygmy perch (Nannoperca australis).

The Journal of heredity·2026
Same journal

The complete genomes of two hybridizing field crickets, Gryllus pennsylvanicus and Gryllus firmus.

The Journal of heredity·2026
Same journal

Chromosome-level genome assembly and annotation of the transverse lady beetle Coccinella transversoguttata.

The Journal of heredity·2026
Same journal

A Chromosome-Level Assembly of the Pine Processionary Moth (Thaumetopoea pityocampa) genome.

The Journal of heredity·2026
See all related articles

This study confirms X-linked recessive inheritance for canine ectodermal dysplasia (ED) in a German shepherd pup. The findings suggest ED in this pup resulted from a new mutation, establishing a colony for further research.

Area of Science:

  • Veterinary Genetics
  • Comparative Pathology
  • Dermatology

Background:

  • Ectodermal dysplasia (ED) is a group of disorders affecting ectodermal structures.
  • Canine ED shares similarities with human hypohidrotic ectodermal dysplasia (HED) and mouse models, suggesting potential homologous gene defects.
  • Previous studies suggested X-linked inheritance in dogs, but definitive confirmation was lacking.

Purpose of the Study:

  • To investigate the inheritance pattern of a novel ectodermal dysplasia phenotype in a German Shepherd pup.
  • To confirm or refute X-linked recessive inheritance for canine ED.
  • To establish a colony for studying this specific ED mutation.

Main Methods:

  • Clinical examination of a German Shepherd pup with hairlessness and dental abnormalities.

Related Experiment Videos

  • Histopathological analysis of skin and footpad biopsies to assess adnexal structures.
  • Family studies and experimental matings involving the affected pup (propositus).

    • Main Results:

    • The affected pup exhibited symmetrical hairlessness, missing, and misshapen teeth.
    • Biopsies revealed a complete absence of hair follicles, adnexal structures, and eccrine glands in affected skin and footpads.
    • Family and experimental mating studies provided strong evidence for X-linked recessive inheritance of ED.
    • Statistical analysis indicated the ED in this case likely arose from a new mutation.

    Conclusions:

    • The findings confirm X-linked recessive inheritance for ectodermal dysplasia in this canine case.
    • The observed phenotype is attributed to a new mutation, distinct from previously reported canine ED cases.
    • A colony of affected dogs has been established for ongoing research into canine ectodermal dysplasia genetics and pathology.