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Updated: Jul 29, 2026

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Published on: April 9, 2014
Single-dose pharmacokinetics of thalidomide in human immunodeficiency virus-infected patients
S C Piscitelli1, W D Figg, B Hahn
1Department of Pharmacy, Clinical Center, National Institutes of Health, Bethesda, Maryland 20892, USA. spisc@nih.gov
Abstract:
The pharmacokinetics of thalidomide in nine human immunodeficiency virus-infected patients were studied. Single doses of thalidomide were well absorbed, with mean peak concentrations (+/- standard deviations) of 1.17 +/- 0.21 and 3.47 +/- 1.14 microg/ml in the 100- and 300-mg dosing groups, respectively, and the mean elimination half-life was approximately 6 h. Adverse effects were mild, with drowsiness being reported for seven of nine patients.
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