Related Experiment Video
Updated: Jul 31, 2026

A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
Hepatitis G virus encodes protease activities which can effect processing of the virus putative nonstructural
A S Belyaev1, S Chong, A Novikov
1Genelabs Technologies, Inc., Redwood City, California 94063, USA. alexb@genelabs.com
Abstract:
The genome of a recently identified virus, hepatitis G virus (HGV), shows considerable homology to hepatitis C virus (HCV). Two HGV proteases similar to nonstructural proteins NS2 and NS3 of HCV were identified, and their cleavage site specificity was investigated. Amino acids essential for the protease activities were determined by mutation analysis. NS4A of HGV was demonstrated to be a cofactor for NS3-mediated proteolysis, with a region critical for activity residing between Leu1561, and Ala1598.
Related Concept Videos
Leaky Scanning
Viruses with RNA Genomes
Hepatitis
Inhibitors of Viral Protein Synthesis
Viral Hepatitis I: Introduction
Inhibitors of Virion Maturation and Assembly

