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Preferential localization of human CD5+ B cells in the peritoneal cavity
S Nisitani1, M Murakami, T Akamizu
1Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan.
Scandinavian Journal of Immunology
|January 8, 1998
Abstract:
In a transgenic mouse model of autoimmune haemolytic anaemia, CD5+ B lymphocytes localized in the peritoneal cavity are shown to play an important role in the onset of autoimmune disease. The authors have examined whether CD5+ B cells are present in the peritoneal cavity of 12 human individuals with non-invasive gastrointestinal tumours and found that in humans CD5+ B cells preferentially lodge in the peritoneal cavity as compared to the peripheral blood and spleen while the numbers of the peritoneal B lymphocytes in humans are much lower than in mice and vary widely between individuals.