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Insulin-like growth factors as determinants of follicular fate
1Departments of Obstetrics/Gynecology and Physiology, University of Maryland School of Medicine, Baltimore 21201, USA.
Objective:
To review the English-language literature as it relates to the rat intraovarian insulin-like growth factor (IGF) system, special emphasis being placed on the hypotheses under study.
Methods:
A thorough literature review of the English-language literature.
Results:
Current data support the view that intraovarian IGF-I may act as an amplifier of gonadotropin hormonal action. The role of IGF-I as a determinant of follicular fate remains a matter of study.
Conclusions:
The intraovarian IGF-I system may play a central role in ovarian physiology by amplifying gonadotropin hormonal action and, possibly, by playing a role in determining follicular fate.