Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Borna disease virus and the brain

D Gonzalez-Dunia1, C Sauder, J C de la Torre

  • 1Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Brain Research Bulletin
|January 1, 1997
PubMed
Summary

Borna disease virus (BDV) persists in the central nervous system (CNS), causing behavioral changes and potentially contributing to human neuropsychiatric diseases. Further research into this neurotropic virus is crucial for understanding brain disorders.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ASO Visual Abstract: Disparities in the Surgical Management of the Axilla by Self-Identified Race in the Multicenter Neoadjuvant I-SPY2 Trial.

Annals of surgical oncology·2025
Same author

Towards a Large-Scale Assessment of the Relationship between Biological and Chronological Aging: The INSPIRE Mouse Cohort.

The Journal of frailty & aging·2021
Same author

Nanowire based bioprobes for electrical monitoring of electrogenic cells.

Journal of physics. Condensed matter : an Institute of Physics journal·2018
Same author

TREATMENT OF BREAST CANCER: IMO STATE NIGERIA VERSUS INDIANA, USA WOMEN - COMPARATIVE ANALYTIC STUDY.

Journal of the West African College of Surgeons·2016
Same author

Construction and rapid testing of synthetic and modified toxin gene sequences CryIA (b&c) by expression in maize endosperm culture.

Plant cell reports·2013
Same author

Arenavirus diversity and evolution: quasispecies in vivo.

Current topics in microbiology and immunology·2006

Area of Science:

  • Neurovirology
  • Central Nervous System (CNS) Infections
  • Behavioral Neuroscience

Background:

  • Persistent viral infections in the CNS can lead to progressive neurological disorders.
  • The etiology of many human mental diseases remains unknown, with viruses being a potential contributing factor.
  • Borna disease virus (BDV) is a neurotropic virus causing CNS disease and behavioral abnormalities in animals.

Purpose of the Study:

  • To investigate the mechanisms of viral persistence in the CNS and their impact on brain function.
  • To explore the role of BDV as a model for understanding virus-cell interactions in the CNS.
  • To examine the association between BDV and human neuropsychiatric diseases.

Main Methods:

  • Utilizing clinical, epidemiological, and virological evidence.

Related Experiment Videos

  • Studying BDV as a model organism for CNS viral persistence.
  • Analyzing seroepidemiological data and molecular studies.

    • Main Results:

    • BDV causes CNS disease and behavioral abnormalities in various species.
    • BDV serves as a prototype for a new virus family, offering insights into neurotropic infections.
    • Evidence suggests a link between BDV and certain human neuropsychiatric conditions.

    Conclusions:

    • BDV persistence in the CNS can lead to neurodevelopmental abnormalities, immune-mediated damage, and altered brain homeostasis.
    • BDV represents a significant model for studying the consequences of viral persistence in the CNS.
    • Further investigation of BDV and related viruses is warranted due to their potential role in human mental health.