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Effects of monosialoganglioside on a new model of tardive dyskinesia
M A Vital1, R Frussa-Filho, J Palermo-Neto
1Department of Pharmacology, Federal University of Paraná, Curitiba.
Abstract:
1- The effects of monosialoganglioside GM1 were studied on a new model of tardive dyskinesia, i.e., the frequency of spontaneous tongue protrusions in rats repeatedly treated with reserpine. 2- Rats were co-treated with vehicle (VEH) or reserpine (RES) (0.1 mg/kg, s.c., every other day) and saline (SAL) or GM1 (5 mg/kg, i.p., every day) for 30 days and observed for tongue protrusions on days 10, 20 and 30. 3- During each test day animals of the RES + SAL group exhibited an increase in tongue protrusions relative to rats of the VEH + SAL group. However, rats of the RES + GM1 group showed an increased frequency of tongue protrusions only on day 10, when compared to animals of the VEH + SAL group. There were no significant differences in tongue protrusion frequency between the VEH + GM1 and the VEH + SAL groups. 4- These results differ from previous studies which reported a facilitatory effect of GM1 co-administration on conventional behavioral animal models of tardive dyskinesia. The possibility is raised that GM1 attenuates the reserpine-induced increase in tongue protrusions through its protective effect on glutamate/oxidative stress neurotoxicity.
Insights
Monosialoganglioside GM1 showed a limited effect on reserpine-induced tardive dyskinesia in rats. GM1 only transiently reduced tongue protrusions, suggesting a potential protective role against neurotoxicity.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Tardive dyskinesia is a movement disorder often associated with long-term antipsychotic use.
- Reserpine-induced tongue protrusions in rats serve as a model for tardive dyskinesia.
- Monosialoganglioside GM1 has been investigated for neuroprotective properties.
Purpose of the Study:
- To investigate the effects of monosialoganglioside GM1 on a novel rat model of tardive dyskinesia.
- To determine if GM1 can attenuate reserpine-induced spontaneous tongue protrusions.
Main Methods:
- Rats were treated with reserpine (RES) or vehicle (VEH) and monosialoganglioside GM1 (GM1) or saline (SAL) for 30 days.
- Spontaneous tongue protrusions were quantified on days 10, 20, and 30.
- Behavioral observations were compared between treatment groups.
Main Results:
- Reserpine treatment significantly increased tongue protrusions compared to vehicle controls.
- GM1 co-administration with reserpine only showed a significant increase in tongue protrusions on day 10.
- No significant differences in tongue protrusions were observed between vehicle + GM1 and vehicle + saline groups.
Conclusions:
- GM1 demonstrated a limited and transient effect on reserpine-induced tardive dyskinesia in this model.
- These findings contrast with previous studies suggesting a facilitatory effect of GM1.
- GM1 may attenuate reserpine-induced effects via protection against glutamate/oxidative stress neurotoxicity.