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Incidence and persistence of anti-Kell after transfusion of Kell-positive blood
A Schabel1, A L König, M R Schiebel
1Institut für Transfusionsmedizin, Katharinenhospital, Stuttgart, Germany.
116 Kell-negative patients who had received at least one Kell-positive blood unit were tested about 3 and 12 months after transfusion. Antibody screening was performed by tube test and by gel centrifugation; both methods yielded identical results. After 3 months, anti-Kell was detected in 11 (9.5%) patients. Antibody titers using K+, k+ cells ranged from 1:1 to 1:128 with a predominance of low titers. Titers using K+, k- cells tended to be higher by one step; one anti-Kell could only be demonstrated with K+, k- cells. After about 12 months, anti-Kell could no longer be detected in 5 of the 11 patients (45.5%).
116 Kell-negative patients who had received at least one Kell-positive blood unit were tested about 3 and 12 months after transfusion. Antibody screening was performed by tube test and by gel centrifugation; both methods yielded identical results. After 3 months, anti-Kell was detected in 11 (9.5%) patients. Antibody titers using K+, k+ cells ranged from 1:1 to 1:128 with a predominance of low titers. Titers using K+, k- cells tended to be higher by one step; one anti-Kell could only be demonstrated with K+, k- cells. After about 12 months, anti-Kell could no longer be detected in 5 of the 11 patients (45.5%).