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Trace elements burden in geriatric hemodialysis patients: a prospective multicenter collaborative study

K Y Hung¹, C Y Ho, Y M Kuo

¹Department of Internal Medicine, National Taiwan University Hospital, Taipei, ROC.

The International Journal of Artificial Organs

|January 9, 1998

Summary

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Geriatric hemodialysis (HD) patients exhibit elevated blood aluminum and decreased plasma zinc levels. Trace element imbalances are linked to aging and HD therapy, warranting further investigation in this population.

Area of Science:

Nephrology
Geriatrics
Trace Element Metabolism

Background:

Hemodialysis (HD) and aging can disrupt the body's trace element (TE) status.
Understanding TE imbalances is crucial for geriatric HD patients.

Purpose of the Study:

To investigate the impact of aging and HD therapy on TE levels in elderly HD patients.
To compare TE status between geriatric HD patients and healthy elderly controls.

Main Methods:

A multicenter study involving 151 geriatric HD patients and 112 elderly controls.
Blood and plasma TE levels (Pb, Cd, Hg, Cu, Zn, Al) measured using atomic absorption spectrophotometry.
Statistical analysis included Student's t-test and linear regression.

Main Results:

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Geriatric HD patients showed significantly higher blood aluminum (Al) and lower plasma zinc (Zn) levels compared to controls.
Blood copper (Cu) and lead (Pb) were higher in HD patients, while cadmium (Cd) and mercury (Hg) were similar.
Plasma Zn decreased with longer dialysis duration and showed an inverse correlation with age.

Conclusions:

Geriatric HD patients experience significant TE imbalances, particularly elevated Al and reduced Zn.
Findings provide a basis for future research on TE disturbances in chronic HD populations.
TE status is influenced by both aging and hemodialysis treatment.