Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Circulating immunoblasts in polymyalgia rheumatica

A A Eghtedari, W Esselinckx, P A Bacon

    Annals of the Rheumatic Diseases
    |April 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides.

    Arthritis and rheumatism·2012
    Same author

    The Use of Quantitative Thermography to Assess the Anti-inflammatory Dose Range for Fenclofenac.

    Proceedings of the Royal Society of Medicine·2010
    Same author

    Intracellular calcium signalling patterns reflect the differentiation status of human T cells.

    Clinical and experimental immunology·2008
    Same author

    Impaired endothelial function in systemic lupus erythematosus.

    Lupus·2007
    Same author

    Infliximab leads to a rapid but transient improvement in endothelial function in patients with primary systemic vasculitis.

    Annals of the rheumatic diseases·2005
    Same author

    Endothelial cell dysfunction in systemic vasculitis: new developments and therapeutic prospects.

    Current opinion in rheumatology·2004
    Same journal

    Mapping inequalities in rheumatology care in Europe: the first edition of the EULAR RheumaFacts project.

    Annals of the rheumatic diseases·2026
    Same journal

    Commentary on 'Assessing the performance of AI chatbots in answering patients common questions about low back pain'.

    Annals of the rheumatic diseases·2026
    Same journal

    Response to Correspondence on 'Safety and immunogenicity of the recombinant zoster vaccine in patients with rheumatoid arthritis using abatacept: a pilot multicentre, double-blind, randomised controlled trial'.

    Annals of the rheumatic diseases·2026
    Same journal

    Correspondence on 'Safety and immunogenicity of the recombinant zoster vaccine in patients with rheumatoid arthritis using abatacept: a pilot multicentre, double-blind, randomised controlled trial' by Hawkins et al.

    Annals of the rheumatic diseases·2026
    Same journal

    Response to correspondence on 'Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis' by Kaundal et al.

    Annals of the rheumatic diseases·2026
    Same journal

    Correspondence on 'Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis' by Kaundal et al.

    Annals of the rheumatic diseases·2026
    See all related articles

    Elevated immunoblasts in peripheral blood are common in polymyalgia rheumatica (PMR) and correlate with disease activity. Detecting these cells aids in assessing PMR activity, especially with low erythrocyte sedimentation rates (ESR).

    Area of Science:

    • Immunology
    • Rheumatology
    • Clinical Medicine

    Background:

    • Polymyalgia rheumatica (PMR) is an inflammatory condition.
    • The role of circulating immunoblasts in PMR is not well understood.
    • Assessing PMR disease activity can be challenging, particularly with low erythrocyte sedimentation rates (ESR).

    Purpose of the Study:

    • To investigate the prevalence of circulating immunoblasts in patients with polymyalgia rheumatica (PMR).
    • To determine if the presence and levels of circulating immunoblasts correlate with PMR disease activity.
    • To evaluate the utility of detecting circulating immunoblasts as a biomarker for PMR.

    Main Methods:

    • Peripheral blood samples were collected from 29 patients with PMR and control groups.
    • The percentage of circulating immunoblasts was quantified.

    Related Experiment Videos

  • Correlation analysis was performed between immunoblast levels, erythrocyte sedimentation rate (ESR), and clinical assessment of disease activity.
  • Serial studies were conducted on some patients, including during steroid therapy.

    • Main Results:

    • A significantly higher proportion of PMR patients (18/29) had elevated circulating immunoblasts compared to healthy young controls (<0.5%) and elderly controls (1/12).
    • The presence of circulating immunoblasts strongly correlated with disease activity, as measured by ESR and clinical evaluation.
    • Initiation of steroid therapy led to a concurrent decrease in both ESR and circulating immunoblasts.
    • Elevated immunoglobulins were more frequent in PMR patients with circulating immunoblasts.

    Conclusions:

    • Circulating immunoblasts are frequently detected in polymyalgia rheumatica (PMR) patients and indicate active disease.
    • Measuring circulating immunoblasts can serve as a valuable additional tool for assessing PMR activity, especially when ESR is low.
    • The findings support an immunological basis for PMR and suggest a potential role for immunoblasts in its pathogenesis.