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Choroidal haemodynamics in glaucoma

H F Duijm1, T J van den Berg, E L Greve

  • 1Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Netherlands.

The British Journal of Ophthalmology
|January 10, 1998
PubMed
Summary
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This study quantifies choroidal hemodynamics, finding significantly prolonged blood refreshment times in normal pressure glaucoma (NPG) patients, indicating slower blood flow in the peripapillary choroid.

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Choroidal Hemodynamics

Background:

  • Glaucoma involves optic nerve damage, potentially linked to impaired blood flow.
  • Peripapillary choroidal hemodynamics are crucial for optic nerve health.
  • Differences in choroidal blood flow may exist between healthy individuals and glaucoma patients.

Purpose of the Study:

  • To quantify peripapillary choroidal hemodynamics.
  • To assess hemodynamic differences in normal subjects, ocular hypertensive (OHT), primary open-angle glaucoma (POAG), and normal pressure glaucoma (NPG) patients.

Main Methods:

  • Video fluorescein angiography was performed on 118 participants (22 normal, 12 OHT, 48 POAG, 46 NPG).
  • Dye buildup curves were modeled to determine blood refreshment time (tau), maximal fluorescence (Fdt), and time of first fluorescence (t0).

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  • Hemodynamic parameters were analyzed for the optic disc and surrounding areas.

    • Main Results:

    • Maximal fluorescence (Fdt) was lower in POAG and NPG patients.
    • No significant difference in the time of first fluorescence (t0) was observed across groups.
    • Choroidal blood refreshment time (tau) was significantly longer in NPG and POAG patients compared to controls, with the slowest times in NPG patients.

    Conclusions:

    • Parametrization of dye curves using a compartmental model effectively quantifies choroidal hemodynamics.
    • Prolonged peripapillary choroidal blood refreshment time, particularly in NPG patients, suggests slower choroidal hemodynamics in this group.