[Electrocardiographic changes in patients with acute leukoses treated with rubidomycin or adriamycin at the Internal...

Electrocardiographic changes in patients with acute leukoses treated with Rubidomycin were observed. In 28 out of 40 followed-up patients changes were found in the form of sinus tachycardia, in 3 of them rhythm changes were observed in the form of extra systols, in 6 low segment S-T, in 12 changes of T waves (lower or isoelectric in 5, negative in 3, and high, pointed in 4 patients). In one patient there was found more prominent right axial deviation and the appearance of small Q in the site not seen before. In addition ot ECG, blood pictue and electrolytes were examined. Parallel occurence of anaemia and sinus tachycaria were found, while electrolytes mostly remained in normal limits. More significant and multiple changes were found in one patient, most often when the administration of a drug was followed by ECG. Lack of appearance of ECG changes in a certain number of our patinets most probably resulted from undue recording, and not from the harmful effect of a drug.