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Related Experiment Videos

The simple in vitro thrombogenic test: modified methods for same priming pumps

E Tayama1, S Ohtsubo, T Nakazawa

  • 1Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.

Artificial Organs
|January 10, 1998
PubMed
Summary
This summary is machine-generated.

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This study developed a modified in vitro thrombogenic test for blood pumps. Heparin-coated pumps demonstrated improved antithrombogenicity compared to non-coated ones in this pilot study.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Devices
  • Hemocompatibility Studies

Background:

  • Improving antithrombogenicity is crucial for blood pump development.
  • Previous in vitro tests predicted thrombogenic areas in blood pumps.
  • Standardized testing methods are needed for evaluating blood pump thrombogenicity.

Purpose of the Study:

  • To modify and validate an in vitro thrombogenic test for blood pumps with identical priming volumes.
  • To compare the antithrombogenicity of heparin-coated versus non-coated centrifugal blood pumps.
  • To assess the feasibility of simultaneous multi-pump evaluation using a single blood source.

Main Methods:

  • A modified in vitro thrombogenic test was developed, eliminating the blood reservoir for identical priming volumes (53 ml).

Related Experiment Videos

  • Nikkiso centrifugal pumps (non-coated vs. heparin-coated) were tested simultaneously in compact mock loops.
  • Fresh heparinized human blood (activated clotting time [ACT] 150-250 s) was used for 4 or 6-hour trials.

    • Main Results:

    • Heparin-coated pumps exhibited a significantly longer thrombus-free period compared to non-coated pumps.
    • Thrombus formation consistently occurred in locations previously identified in in vivo studies.
    • The modified test allowed for simultaneous evaluation of multiple pumps using the same blood source.

    Conclusions:

    • The modified in vitro thrombogenic test is a feasible and valuable pilot study for assessing blood pump antithrombogenicity.
    • Heparin coating enhances the hemocompatibility of centrifugal blood pumps.
    • This method facilitates efficient, simultaneous comparison of different blood pump designs.