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Hydroxyurea-induced leg ulceration in 14 patients
P J Best1, M S Daoud, M R Pittelkow
1Mayo Clinic, Rochester, Minnesota, USA.
Background:
Hydroxyurea is an antineoplastic agent commonly used to treat myeloproliferative disorders and other nonneoplastic conditions.
Objective:
To further define the typical features of hydroxyurea-related cutaneous ulcers of the leg.
Design:
Retrospective, descriptive study of the medical records of patients who developed leg ulcers while receiving hydroxyurea therapy.
Setting:
A tertiary care medical center.
Patients:
Patients with myeloproliferative disorders who were treated with hydroxyurea.
Results:
14 patients with extremely painful leg ulcers were identified. The most common ulcer site was the malleoli. Multiple ulcers were seen in 64% of patients. Patients had received hydroxyurea for an average of 6 years before ulcers developed. All ulcers healed after discontinuation of hydroxyurea treatment, and 2 patients developed ulcers after treatment was restarted.
Conclusion:
Hydroxyurea induces painful leg ulcers that are usually difficult to treat and require cessation of hydroxyurea therapy.
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