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Hydroxyurea-induced leg ulceration in 14 patients
P J Best1, M S Daoud, M R Pittelkow
1Mayo Clinic, Rochester, Minnesota, USA.
Hydroxyurea can cause painful leg ulcers, often on the ankles, in patients with myeloproliferative disorders. Discontinuing hydroxyurea treatment is necessary for these ulcers to heal.
Area of Science:
- Dermatology
- Oncology
- Pharmacology
Background:
- Hydroxyurea is a vital antineoplastic medication for myeloproliferative disorders.
- Its use extends to nonneoplastic conditions, highlighting its broad therapeutic applications.
Observation:
- This study investigated the characteristics of leg ulcers associated with hydroxyurea therapy.
- A retrospective analysis of 14 patients treated at a tertiary care center was conducted.
Findings:
- Patients developed extremely painful leg ulcers, frequently on the malleoli, after an average of 6 years of hydroxyurea use.
- Multiple ulcers were observed in 64% of patients.
- Ulcer healing occurred upon hydroxyurea discontinuation, with recurrence noted in two patients after restarting the medication.
Implications:
- Hydroxyurea can induce severe leg ulcers that are challenging to manage.
- Cessation of hydroxyurea is the primary treatment for these ulcers.
- Awareness of this adverse effect is crucial for clinicians managing patients on hydroxyurea.
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