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Dorsal-ventral signaling in limb development

K D Irvine1, T F Vogt

  • 1Waksman Institute, Rutgers, State University of New Jersey, Piscataway 08854-8020, USA. irvine@mbcl.rutgers.edu

Current Opinion in Cell Biology
|January 13, 1998
PubMed
Summary

Fringe protein is crucial for limb development by regulating Notch signaling at the dorsal-ventral border in both Drosophila and vertebrates. This signaling organizer is maintained by feedback mechanisms.

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • Limb formation relies on signaling between dorsal and ventral cells, establishing an organizer.
  • The dorsal-ventral limb border is a key signaling center for development.

Purpose of the Study:

  • To characterize signaling interactions at the dorsal-ventral limb border.
  • To understand the role of Fringe in Notch signaling during limb development.

Main Methods:

  • Comparative studies in Drosophila and vertebrate models (chicks).
  • Analysis of Notch pathway activation by ligands Serrate and Delta.
  • Investigation of feedback mechanisms maintaining the limb organizer.

Main Results:

  • Fringe protein is essential for limb formation in both Drosophila and vertebrates.
  • Fringe modulates Notch receptor activation by specific ligands (Serrate, Delta).
  • Feedback loops involving neighboring cells maintain the dorsal-ventral boundary organizer.

Conclusions:

  • Fringe plays a conserved role in regulating Notch signaling for limb development.
  • Understanding these signaling pathways provides insights into developmental processes and potential therapeutic targets.

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