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Systemic absorption of gentamicin ear drops

K M Green1, D W Lappin, J W Curley

  • 1Department of Otolaryngology, Royal Preston Hospital, UK.

The Journal of Laryngology and Otology
|January 13, 1998
PubMed

Insights

Topical aminoglycosides treat ear infections but can be absorbed systemically. A case study found significant gentamicin levels in the blood after using Gentisone HC for ear conditions.

Area of Science:

  • Otolaryngology
  • Pharmacology
  • Dermatology

Background:

  • Topical aminoglycosides are frequently prescribed for chronic suppurative otitis media and otitis externa.
  • These preparations are generally considered safe for localized treatment.

Observation:

  • A patient using a topical aminoglycoside preparation, Gentisone HC, experienced unintended systemic absorption.
  • This resulted in a measurable serum gentamicin concentration.

Findings:

  • Serum gentamicin levels reached 6.2 micrograms/ml, indicating significant systemic uptake.
  • This highlights a potential risk associated with topical aminoglycoside use.

Implications:

  • Clinicians should be aware of the potential for systemic absorption of topical aminoglycosides.
  • Monitoring serum levels may be warranted in specific patient populations or with prolonged use.
  • This case underscores the importance of considering systemic effects even with topical medications.

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