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Changes in CD44 isoform expression during inflammatory skin disease

A J Harris1, D Dean, S Burge

  • 1Department of Dermatology, Oxford Radcliffe Hospital Trust, UK.

Clinical and Experimental Dermatology
|May 1, 1997
PubMed
Summary
This summary is machine-generated.

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This study found reduced CD44 variant isoforms on skin keratinocytes in lupus erythematosus and lichen planus. Lymphocytes showed no detectable variant CD44, even with T cell activation, suggesting altered CD44 expression in these inflammatory skin diseases.

Area of Science:

  • Immunodermatology
  • Molecular Biology
  • Cell Surface Glycoproteins

Background:

  • CD44 is a cell surface glycoprotein family involved in cell adhesion, expressed in various tissues.
  • CD44 exhibits diverse isoforms due to variable exon involvement in its extracellular domain.
  • Specific CD44 isoforms are expressed on stimulated T cells and keratinocytes.

Purpose of the Study:

  • To investigate the expression of specific CD44 variant isoforms on epithelial cells and lymphocytes in lupus erythematosus and lichen planus.
  • To compare CD44 isoform expression in inflammatory skin conditions with normal skin.

Main Methods:

  • Utilized monoclonal antibodies targeting CD44 variant exons (v3, v4/5, v6, v8/9) and a pan CD44 marker.
  • Analyzed frozen skin samples from patients with lupus erythematosus (n=10) and lichen planus (n=8).

Related Experiment Videos

  • Compared findings with normal skin samples from nine body sites.

    • Main Results:

    • No detectable levels of CD44 variant isoforms were found on lymphocytes in either inflammatory skin disease, despite T cell activation.
    • A reduction in all investigated CD44 variant isoforms was observed on keratinocytes in some sections of lupus and lichen planus samples.
    • Pan CD44 expression patterns were not detailed but implied to be present.

    Conclusions:

    • The study suggests altered expression of CD44 variant isoforms in inflammatory skin diseases like lupus and lichen planus.
    • Reduced keratinocyte CD44 variant expression may play a role in the pathogenesis of these conditions.
    • The absence of variant CD44 on activated lymphocytes warrants further investigation into CD44's role in immune responses within skin inflammation.