Related Experiment Video
Updated: Aug 11, 2026

Behavioral Phenotyping of Murine Disease Models with the Integrated Behavioral Station (INBEST)
Published on: April 23, 2015
Experimental strategies for the genetic dissection of complex traits in animal models
1The Jackson Laboratory, Bar Harbor, Maine 04609-1500, USA. darvasi@jax.org
Abstract:
Current success in detecting complex trait loci in general, and quantitative trait loci (QTLs) using model organisms in particular, has attracted major biological and biomedical interest. The potential ability to identify genes and their function provides opportunities for new diagnostics and treatments of complex genetic diseases. Despite the success in gene mapping, however, cloning of complex trait loci or QTLs is not straightforward. A major obstacle lies in achieving fine mapping resolution for the detected loci. Compared to the rapid development of sophisticated statistical and molecular tools, development and analysis of experimental designs for various stages in QTL mapping experiments have barely been considered. In this study, novel and existing experimental strategies for QTL analysis are presented and evaluated.
Related Concept Videos
Polygenic Traits
In-vitro Mutagenesis
Genetic Screens
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Mouse Models of Cancer Study
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Epistasis Analysis
Behavioral Genetics and Its Designs
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...

