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Noradrenaline and ATP decrease the secretion of triglyceride and apoprotein B from perfused rat liver

T Yamauchi1, M Iwai, N Kobayashi

  • 1Department of Medical Biochemistry, Ehime University School of Medicine, Shigenobu, Ehime 791-02, Japan.

Pflugers Archiv : European Journal of Physiology
|February 28, 1998
PubMed
Summary
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Sympathetic neurotransmitters noradrenaline and ATP reduce the secretion of triglyceride and apoprotein B (ApoB) from the liver. This suggests a post-transcriptional regulation of very low density lipoprotein (VLDL) release.

Area of Science:

  • Hepatology
  • Neuroendocrinology
  • Lipid Metabolism

Background:

  • Hepatic sympathetic nerves play a role in regulating liver function.
  • Very low density lipoprotein (VLDL) secretion is crucial for lipid transport.
  • Understanding neurotransmitter effects on VLDL is key to metabolic regulation.

Purpose of the Study:

  • To investigate the impact of sympathetic neurotransmitters on hepatic VLDL secretion.
  • To elucidate the mechanisms by which noradrenaline and ATP affect triglyceride and apoprotein B (ApoB) release.

Main Methods:

  • Utilized in situ rat liver perfusion with recirculation.
  • Administered noradrenaline and ATP to assess effects on perfusate triglyceride and ApoB.
  • Investigated adrenoceptor involvement and mRNA levels.

Related Experiment Videos

Main Results:

  • Noradrenaline and ATP suppressed triglyceride and ApoB secretion from the liver.
  • The suppressive effect on triglyceride was mediated via alpha-adrenoceptors and occurred independently of hemodynamic changes.
  • Hepatic mRNA levels for ApoB remained unchanged, suggesting post-transcriptional regulation.

Conclusions:

  • Sympathetic neurotransmitters noradrenaline and ATP inhibit hepatic secretion of ApoB-containing lipoproteins, including VLDL.
  • The regulation likely occurs at a post-transcriptional level, impacting lipoprotein assembly or release.
  • This highlights a novel neuro-hepatic pathway influencing lipid metabolism.