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Related Experiment Videos

Circadian changes in the sweating-to-vasoconstriction interthreshold range

F Tayefeh1, O Plattner, D I Sessler

  • 1Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California 94143-0648, USA.

Pflugers Archiv : European Journal of Physiology
|February 28, 1998
PubMed
Summary

The precision of human body temperature control, measured by the interthreshold range, is significantly reduced at 3 a.m. compared to other times of day, indicating diminished autonomic thermoregulation even without sleep.

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Area of Science:

  • Physiology
  • Thermoregulation
  • Circadian Rhythms

Background:

  • Autonomic defenses maintain core body temperature within a narrow interthreshold range.
  • The precision of this thermoregulation across the circadian cycle is not well understood.
  • A typical circadian core temperature cycle spans approximately 0.8 degrees C.

Purpose of the Study:

  • To evaluate the precision of the human thermoregulatory interthreshold range at different times of the day.
  • To determine if circadian variations affect the precision of autonomic body temperature control.

Main Methods:

  • Ten male volunteers were tested at 3 a.m., 8 a.m., 3 p.m., and 8 p.m.
  • Sweating and vasoconstriction thresholds were determined by controlled peripheral warming and central cooling.

Related Experiment Videos

  • The interthreshold range was calculated as the difference between core temperatures at sweating and vasoconstriction onset.

    • Main Results:

    • The interthreshold range at 3 a.m. was found to be twice as large as at other tested times (P<0.05).
    • This indicates a significant reduction in thermoregulatory precision during the early morning hours.
    • Core body temperature control precision is demonstrably altered by circadian timing.

    Conclusions:

    • Autonomic control of body temperature is reduced at 3 a.m., irrespective of sleep status.
    • Circadian variations impact the precision of thermoregulation, challenging the notion that only the target temperature shifts.
    • These findings highlight a potential vulnerability in thermoregulatory function during specific circadian phases.