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Rapid and reliable measurement of highly elevated blood ammonia concentrations in children
M H de Keijzer1, B S Jakobs, R W Brandts
1Department of Clinical Chemistry, University Hospital St. Radboud, Nijmegen, The Netherlands.
European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies
|January 14, 1998
Abstract:
Newborns and children may suffer from extremely high ammonia levels in their blood. We evaluated a fast, reliable micromethod, based on the Blood Ammonia Checker II (BAC II) in combination with the dilution with fresh whole blood. Comparison of the proposed method with an enzymatic method revealed a statistically significant correlation. We conclude that the dilution of patient's blood with fresh whole blood extends the measuring range of ammonia on the BAC II analyzer from 286 mumol/l to about 700 mumol/l.