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Related Experiment Videos

A myogenic basis for the overactive bladder

A F Brading1

  • 1University Department of Pharmacology, Oxford, United Kingdom.

Urology
|January 14, 1998
PubMed
Summary
This summary is machine-generated.

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Spontaneous pressure rises in overactive bladder, specifically detrusor instability (DI), are caused by the bladder muscle itself (myogenic). Changes in detrusor muscle properties, potentially due to partial denervation, lead to increased excitability and contractions.

Area of Science:

  • Urology
  • Physiology

Background:

  • Overactive bladder (OAB) and detrusor instability (DI) are characterized by spontaneous pressure rises.
  • The underlying mechanisms of these pressure rises require further elucidation.

Purpose of the Study:

  • To summarize evidence supporting a myogenic origin for spontaneous pressure rises in detrusor instability.
  • To explore the cellular and structural changes contributing to detrusor overactivity.

Main Methods:

  • Electrophysiologic studies of detrusor myocytes.
  • Muscle strip tension studies.
  • In vivo animal models and microscopic bladder wall analysis.

Main Results:

  • Evidence indicates changes in detrusor myocyte properties, structure, and innervation.

Related Experiment Videos

  • Partial denervation may alter smooth muscle properties, increasing excitability and cell-to-cell activity spread.
  • These alterations facilitate coordinated, myogenic detrusor contractions.

    • Conclusions:

    • Alterations in detrusor myocyte properties are essential for the pressure rises observed in detrusor instability.
    • A myogenic mechanism underlies detrusor instability regardless of its etiology.