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Related Experiment Videos

A sensitive ocular perfusion apparatus measuring outflow facility

C Kee1, T Hong, K Choi

  • 1Department of Ophthalmology, Samsung Medical Center College of Medicine, Sungkyunkwan University, Korea. cwkee@smc.samsung.co.kr

Current Eye Research
|January 14, 1998
PubMed
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This study presents a new perfusion apparatus for measuring outflow facility. The device offers stable and sensitive measurements of intraocular pressure changes in both live and artificial eyes.

Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Fluid Dynamics

Background:

  • Accurate measurement of outflow facility is crucial for understanding intraocular pressure regulation.
  • Existing methods may lack the stability and sensitivity required for detecting subtle physiological changes.

Purpose of the Study:

  • To develop and validate an improved apparatus for measuring ocular outflow facility.
  • The apparatus utilizes a one- and two-level, constant pressure perfusion technique.

Main Methods:

  • A computer-controlled system adjusts fluid reservoir height to maintain constant intraocular pressure (IOP).
  • Fluid flow rate is calculated using the formula Q = (Pres - IOP)/R.
  • Outflow facility is determined by the change in flow rate (ΔQ) divided by the change in pressure (ΔP).

Related Experiment Videos

  • Perfusion experiments were conducted on live albino rat eyes and artificial steel eyes.

    • Main Results:

    • The apparatus demonstrated high stability and sensitivity in perfusion experiments.
    • Outflow facility measurements were recorded for both live rat eyes (0.0507 ± 0.0039 μL/min/mmHg) and artificial eyes (0.3546 ± 0.0034 μL/min/mmHg).

    Conclusions:

    • The developed perfusion apparatus is effective for measuring outflow facility.
    • It is capable of detecting subtle changes in outflow facility both in vivo and in vitro.